Gain insight into the interaction network established with ULTImate Y2H™ technology
by taking advantages of experimental domains and already known functional or structural domains.
Knowing which protein interacts with which is the first step when exploring a pathway. Go one step further and find out what are the biochemical mechanisms that support the experimental interactions you just found and what are proteins’ roles within the pathway. In that purpose, Hybrigenics ULTImate Y2H™ provides you not only with reliable partners for your protein of interest, but also with experimental interaction domains (SID®).
Furthermore, we have enriched all proteins with domain annotations using standard bio-informatics algorithms (InterproScan, TMHMM and SignalP).
Finally, we add to each screen result file a graphical file, DomSight®, that displays both experimental and already known domains located on the 2D protein structures. DomSight® will help you to understand at one glance how proteins interact and what are their respective roles within the pathway. To be fully practical DomSight is available as a PDF file and uses a simple domain color codification.
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