More than 900 customers worlwide have already used our services. Please have a look at what our customers say about us...

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EUROPE

"My laboratory carried out a Y2H screen using a brain fetal library to find proteins interacting with a cleaved domain of a transmembrane protein.  Every part of the procedure was clearly explained by the team and after a few months I received clear results.  Interacting proteins identified by the Y2H screen were confirmed by other methods and in the end, the results were very helpful to go on with our research.  The price that I paid was very cheap considering the importance of the results and the speed to get them."
Dr. Bernard Rogister, University of Liege, Belgium.

"My laboratory carried out a Y2H screen with Hybrigenics using a human fibroblast cDNA library. I was very pleased with the results that we got. When I first contacted Hybrigenics about carrying out a screen, they were very helpful with explaining the technical detail about how the screen was going to be carried out, the reagents that I needed to provide, the potential problems that may arise and the what steps would be taken should these problem be encountered. The customer service was outstanding and I very much appreciated the one to one contact I had with them. I was constantly kept informed about the progress of the project and following completion of the project, the results of the screen were explained thoroughly. Given the level of professionalism, service and the reasonable price, I would highly recommend Hybrigenics to any other researcher interested in carrying out a Y2H screen."
Dr. Grant Stewart, University of Birmingham, United Kingdom.

"I first used the HYBRIGENICS 1-by-1 Y2H service to test specific protein-protein interactions in my project. The result was very satisfying and then I asked HYBRIGENICS to perform ULTImate Y2H screens for two proteins I am working on. The result came back within three months with complete detailed bioinformatics analysis of the positive clones which is very helpful for further investigation. Also the staff in HYBRIGENICS is very friendly to help in each step of the experiment from the design of the bait to interpret the result data. It is a pleasant experience to work with HYBRIGENICS and I would highly recommend HYBRIGENICS to people who want to do yeast-two-hybrid screen."
Dr. Paul WU, Cambridge University, United Kingdom.

"I learnt about Hybrigenics from a colleague who recommended this company warmly. Having performed several two-hybrid screens myself, I was very impressed by the professionalism at Hybrigenics. The data they obtained for us were of really high quality and formed the basis for several publications"
Pr. Harald Stenmark, Centre for cancer Biomedicine, University of Oslo.

"My laboratory carried out several screens with Hybrigenics in order to identify the partners of Rab GTPases, key regulators of intracellular traffic in eukaryotic cells. The results have been impressive and have led to several publications, including two recently in Nature Cell Biology (Miserey-Lenkei et al, 2010; Dambournet et al., 2011). In addition to the high quality of the work, I find the prey fragment analysis that Hybrigenics provides for each screen very helpful. Of note, the Hybrigenics staff is not only competent, but friendly and can be contacted at any time for advice and assistance".
Dr. Bruno Goud, Institut Curie, France.

"Hybrigenics performed Y2H screens for different proteins we are interested in. All these screens were very successful and identified several novel protein interactions which we confirmed using other methods. The most remarkable screen was conducted with a protein showing autoactivation in the Y2H system. Hybrigenics followed two strategies to identify interaction partners. One was the MBmate system, which already identified some novel interaction partners. The other strategy was based on a domain mapping which identified the autoactivating part of the protein, which was rather unexpected, and was followed up by an ULTImate screen using other parts of the protein. These latter screens revealed a high number of novel interaction partners of putative functional relevance. Hybrigenics provides a high quality service package to discover novel interactions based on scientific experience and assistance combined with complex libraries. "
Dr. Guido Hermey, Center for Molecular Neurobiology Hamburg,Germany.

"We were delighted with Hybrigenics services. 3 months only were necessary for them to sub-clone the bait, test 90 millions of interactions and isolate many potential binding partners, some with very high confidence. Interactions with both the scientific and commercial teams were very pleasant and highly professional. We would definitely use Hybrigenics again and highly recommend it."
Dr. Christine Salaün, Faculté de Médecine Paris Descartes, France.

"Recently, we performed a yeast two-hybrid screen using the service provided by Hybrigenics. This turned out to be a good investment since the bait caused several problems that were efficiently solved by the experts of Hybrigenics. The screen was performed in little time, providing us with a list of putative interactors that have allowed us to dig into new but highly relevant functions of our protein. All in all, given the limited resources of our laboratory we are convinced that confiding to the expertise of Hybrigenics was worth the cost of the service and can only be strongly recommended to other research laboratories."
Dr. Charlotte Kilstrup-Nielsen, University of Insubria, Italy.

"I was very impressed with Hybrigenics in all my dealings with them.  They responded to my queries promptly and thoughtfully both in the planning of the project and as it developed.  It turned out that my initial full-length Y2H bait was a strong auto-activator and so a “Domain Mapping Autoactivator” project was launched in order to conduct the Y2H screen.  A dialogue between myself and Hybrigenics was required to decide which truncations to test.  I was continually impressed with their level of expertise, attention to detail and refreshing interest in the science, and importantly their commitment to keeping the project on schedule.  In all Hybrigenics provided a very professional service and were a pleasure to work with." 
Dr. Michael Taylor, Cardiff University, United Kingdom.

"We have recently used the expertise of Hybrigenics to screen for binding partners in the genome of the parasitic protozoan Trypanosoma brucei. This turned out to be a doubly pleasing experience, not only because the screen was successful beyond expectations, but also because the people at Hybrigenics proved to be very helpful, highly competent, were readily available for support and delivered the results on time."
Pr. Thomas Seebeck, University of Bern, Switzerland.

"We have used Hybrigenics services for one screen using a human cDNA library. We have been very satisfied with the service provided. Obviously the qualities of the library and of the screen were excellent, a large number of clones were screened, and among the positives we found an already known interacting protein. Very useful bioinformatics information about the clones was provided along with the clones' identity. Altogether, the service was very efficient and quick. In addition, at the various steps of the screen, direct interaction, by email or by phone with the technical service was helpful and efficient."
Dr. Bernard de Massy, Institut de Génétique Humaine, Montpellier, France.

"We have used Hybrigenics' services, first for the construction of a highly complex medaka yeast two-hybrid library and then to perform four independent ULTImate Y2H Screens using that library. The screens were in all cases successful and we are very satisfied with the quality of the results, with the timing and with the professional services offered throughout the entire process. I would definitely recommend it to other customers."
Dr. Juan Ramon Martinez Morales, Universidad Pablo de Olavide, Spain.

"Hybrigenics offers a highly professional two-hybrid service. Obtained results are well presented and easily interpreted. Known preys have faithfully been identified, which has proved the very high quality provided by Hybrigenics."
Dr. Peder Madsen, University of Aarhus, Denmark.


"We have used Hybrigenics’ ULTImate Y2H Screening Service 4 times over the last years and we have been successful each time! Hybrigenics staff has been very helpful in the design of the bait construct and their offer is really complete. The data provided are presented in a professional way. I am very satisfied with their service and would recommend to use it."
Dr. Carol Murphy, University of Ioannina, Greece.

"Regarding the Hybrigenics screen I can say that my experience with Hybrigenics was that the whole setting up and screening process was very professional. 80% of the proteins identified as partners to my bait protein were real and co-localize to the bait. This was very useful because my bait is an insoluble cytoskeleton protein. We are very pleased with the results."
Derrick Roy Robinson, University of Bordeaux, France.

"We have used Hybrigenics services for one screen using a human muscle cDNA library. We have been very satisfied with the service provided. A large number of clones were screened, and the screen was successful. Altogether, the HYBRIGENICS staff was very efficient and very friendly to help in each step of the project (regular updates on the progress of the screens)."
Carine Le Goff, Hôpital Necker-Enfants Malades, Paris, France.

" I used Hybrigenics Y2H services to identify new protein-protein interactions using our protein of interest as a bait against their human placenta library. The results of the screening were very satisfying. They contained a detailed analysis of each hit and an estimation of their level of confidence which was helpful. Most of the putative interactors were found more than once suggesting that the screening was performed thoroughly. Importantly, one of the hits really fitted with our previous observations and, once validated, helped to delineate the mechanism of action that we had been struggling to find out. Thus, the screening results were very valuable to us and ultimately led to a publication in Science Signaling. The people at Hybrigenics were really helpful and efficient and I was extremely pleased with their performance. Hybrigenics provides a high quality service and I would strongly recommend it to other scientists."
Dr. Susana Llanos, CNIO, Madrid, Spain.

"I have had two Y2H screens conducted by Hybrigenics. I found my contacts to be helpful and friendly, and they gave clear advice on the pros and cons of particular types of libraries and of different bait designs. The results arrived promptly and were helpfully annotated. This allowed us to identify potential leads quickly and we have made excellent progress. Of the leads we have followed, over 90% have been confirmed by directed Y2H, biochemically, and/or functionally"
Dr. Phil Woodman, Manchester University, United Kingdom.

USA / CANADA / SOUTH AMERICA

"Working with Hybrigenics staff is more like having a collaborator than a service provider. Staff is very knowledgeable and highly responsive. their expertise and novel methodology gives high hit reliability."
Dr. Bhuminder Singh, Vanderbilt University, USA.

"Hybrigenics yeast two-hybrid screening is unparalleled in terms of completeness and quality of service.  Moreover, their services are a tremendous value, as we could not set it up in our lab for even half the cost. Their screens of two of our baits have helped land one grant and will be the backbone for another."
Dr. Scott Hiebert, Vanderbilt University, USA.

 "I have been very happy with the results. They have given us numerous leads for our research. I would definitely use Hybrigenics services again."
Dr. James Schoelz, University of Missouri, USA.

"I requested HYBRIGENICS to perform a Y2H screen to test specific protein-protein interactions in the model plant Arabidopsis thaliana, the system I am working on. The results obtained by HYBRIGENICS were included in a nice paper recently published in Science (Velasquez et al. 2011). The results came back within two months with a very detailed bioinformatics analysis of the positive clones which helped me a lot to redefine my project. In addition, the experimental design of the bait together with the interpretation of the data was done together with the staff in HYBRIGENICS. I would strongly recommend doing Y2H with HYBRIGENICS."
Dr. José M. Estevez,  University of Buenos Aires, Argentina.

 "I was extremely pleased with a recent yeast two hybrid screen that was conducted for our laboratory by Hybrigenics.  Their technology is phenomenal and yielded impressive results that are sure to give us fascinating projects for years to come.  I am particularly impressed with how they are able to narrow down the sites of potential interaction between bait and prey, sometimes to within very small amino acid stretches.  In short, they have provided to me, within a few months, results that had previously taken me years to achieve, which I would say is definitely worth the investment!  Every member of the staff that I contacted was very professional, knowledgeable and friendly on all occasions.  I certainly recommend the Hybrigenics services."
Dr. Clifford Toleman,  St. Jude Children Hospital, USA.

"The technical and sales staff at Hybrigenics has been very supportive in our project so far. They have worked with us every step of the way, on a project that has had numerous technical challenges.  In addition to good service, they seem genuinely curious in the science and have contributed to our critical thinking regarding the work."
Dr. Alex Bassuk, The University of Iowa, USA.

"We have used Hybrigenics services to screen a cDNA library of Arabidopsis for six different baits. We have obtained very good results for all of them.
We have found the support service remarkably efficient and helpful providing scientific assistance and regular updates on the progress of the screens.
We are very satisfied with this company and we will continue to use them in the future."
Pr. Federica Brandizzi, Michigan State University, USA.

"If you are a small, cost-sensitive lab and you are considering a yeast two-hybrid approach, Hybrigenics offers a compelling package of experienced scientists, vectors, procedures, cDNA libraries, robotics, and bioinformatics capable of accelerating your research that is worth considering. Given the limitations of resources (space, time, people, and funds), outsourcing this work to a skilled, dedicated service allows small labs to easily extend their capabilities, generating rapid results of genome-wide screens with high quality control"
Dr. Howard Gershenfeld, University of Texas Southwestern, USA.

"Hybrigenics was up to par for their services, starting from the time the contract was established. There was absolutely no down time on their end.
Our request was executed as we wished."
Dr. Pascale Nantermet, Merck & Co, USA.

 "Hybrigenic’s two-hybrid service is really quite impressive, and their people are a pleasure to work with, I highly recommend them. And, it doesn’t matter how little you pay your post docs, you can’t beat their price."
Dr. Mike Schopperle, Harvard Medical School, USA.

"As a fundamentalist researcher in pain neurophysiology, seeking interaction partners of our potent targets is undoubtedly necessary to unravel underlying mechanisms and address our hypothesis. After reviewing many strategy tracks to perform Yeast-Two-Hybrid screening, our highest scored choice was Hybrigenics. Why? Cost- and time-effective throughput; results under 4 months, cost estimates lower than homemade Y2H for those who don't have an active platform, results layed in a bioinformatics report ranked as highest potential on-target partners. Add to this that graduate students won't jeopardize their projects; they can focus on 10 guaranteed interaction candidates from the beginning instead of hoping to obtain partners after 1 year of Y2H laboratory efforts. Hybrigenics has a reputation built upon a good record, and all this rendered under a professional service. An intelligent way to perform efficient research...I highly recommend!"
Dr. Nicolas Beaudet, Sherbrooke University, Canada.